EINE GLOBALE, MULTIZENTRISCHE, RANDOMISIERTE, VISUS-ASSESSOR-MASKIERTE PHASE-IIIB-STUDIE ZUR BEURTEILUNG DER WIRKSAMKEIT, SICHERHEIT UND PHARMAKOKINETIK EINES 36-WÖCHIGEN NACHFÜLLSCHEMAS FÜR DAS PORT DELIVERY SYSTEM MIT RANIBIZUMAB BEI PATIENTEN MIT EINER NEOVASKULÄREN ALTERSABHÄNGIGEN MAKULADEGENERATION

Drug: Ranibizumab;Device: Port Delivery System with Ranibizumab

Gender: All
Maximum age: N/A
Minimum age: 50 Years
Inclusion Criteria:

- Age = 50 years at time of signing Informed Consent Form

- Initial diagnosis of nAMD within 9 months prior to the screening visit

- Previous treatment with at least three anti- vascular endothelial growth factor
(VEGF) intravitreal injections for nAMD per standard of care within 6 months prior
to the screening visit

- Demonstrated response to prior anti-VEGF intravitreal treatment since diagnosis

- Availability of historical visual acuity data prior to the first anti-VEGF treatment
for nAMD until the time of study enrollment

- BCVA of 34 letters (approximate 20/200 Snellen equivalent) or better

Exclusion Criteria:

- History of vitrectomy surgery, submacular surgery, or other surgical intervention
for AMD in study eye

- Prior treatment with Visudyne?, external-beam radiation therapy, or transpupillary
thermotherapy in study eye

- Previous treatment with corticosteroid intravitreal injection, intraocular device
implantation, previous laser (any type) used for AMD treatment in study eye

- Treatment with anti-VEGF agents other than ranibizumab within 1 month prior to the
enrollment visit in study eye

- Concurrent conjunctival, Tenon's capsule, and/or scleral condition in the
supero-temporal quadrant of the eye that may affect the implantation, subsequent
tissue coverage, and refill-exchange procedure of the PDS implant

- Prior treatment with brolucizumab (at any time prior to the screening visit) in
either eye

- Prior participation in a clinical trial involving any anti-VEGF drugs, within 6
months prior to the enrollment visit in either eye

- Subretinal hemorrhage that involves the center of the fovea, if the hemorrhage is
>0.5 disc area at screening in study eye

- Subfoveal fibrosis or subfoveal atrophy in study eye

- CNV due to other causes, such as ocular histoplasmosis, trauma, central serous
chorio-retinopathy, or pathologic myopia in either eye

- Retinal pigment epithelial tear in study eye

- Any concurrent intraocular condition that would either require surgical intervention
during the study to prevent or treat visual loss that might result from that
condition or affect interpretation of study results in study eye

- Active intraocular inflammation in study eye

- History of vitreous hemorrhage in study eye

- History of rhegmatogenous retinal detachment in study eye

- History of rhegmatogenous retinal tears or peripheral retinal breaks within 3 months
prior to the enrollment visit in study eye

- History of pars plana vitrectomy surgery

- Aphakia or absence of the posterior capsule in study eye

- Spherical equivalent of the refractive error demonstrating more than 8 diopters of
myopia in study eye

- Preoperative refractive error that exceeded 8 diopters of myopia, for Participants
who have undergone prior refractive or cataract surgery in study eye

- Intraocular surgery within 3 months preceding the enrollment visit in study eye

- Uncontrolled ocular hypertension or glaucoma and any such condition the investigator
determines may require a glaucoma-filtering surgery during a participant's
participation in the study in study eye

- History of glaucoma-filtering surgery, tube shunts, or microinvasive glaucoma
surgery in study eye

- History of corneal transplant in study eye

- Any history of uveitis requiring treatment in either eye

- Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis in either
eye

- Uncontrolled blood pressure

- History of stroke within the last 3 months prior to informed consent

- Atrial fibrillation diagnosed or worsened within the last 3 months prior to informed
consent

- History of myocardial infarction within the last 3 months prior to informed consent,

- History of other disease, metabolic dysfunction, or clinical laboratory finding
giving reasonable suspicion of a disease or condition that contraindicates the use
of ranibizumab or placement of the implant and that might affect interpretation of
the results of the study or renders the participant at high risk of treatment
complications in the opinion of the investigator

- Confirmed active systemic infection

- Use of any systemic anti-VEGF agents

- Active cancer within 12 months of enrollment except for appropriately treated
carcinoma in situ of the cervix, non-melanoma skin carcinoma, and prostate cancer
with a Gleason score of <= 6 and a stable prostate-specific antigen for > 12 months

- Previous participation in any non-ocular disease studies of investigational drugs
within 1 month preceding the informed consent

- Non-functioning non-study eye