Treatment of Coronary In-stent Restenosis (ISR) by a Sirolimus Coated or a Paclitaxel Coated Balloon

Inclusion Criteria:

- 18 years of age

- Clinical evidence of stable or unstable angina (acute coronary syndrome) or a positive
functional study

- Patients with = 2 primary in-stent restenosis (ISR) lesions (= 70% diameter stenosis
by visual estimation or =50% and positive functional study) including margin-stenosis
with max 5 mm distance to the stent

Exclusion Criteria:

- Chronic renal insufficiency with serum creatinine levels > 2.0 mg per deciliter

- Known hypersensitivity or contraindications to aspirin, heparin, clopidogrel,
ticlopidine or sirolimus, and sensitivity to contrast media not amenable to
premedication

- Concomitant medical illness associated with a life-expectancy of less than two year

- Lesion length (ISR) > 35 mm, reference vessel diameter < 2.5 mm