Paediatric Hepatic International Tumour Trial

Inclusion Criteria:

- Clinical diagnosis of HB* and histologically defined diagnosis of HB or HCC.

*Histological confirmation of HB is required except in emergency situations where:

- a) the patient meets all other eligibility criteria, but is too ill to undergo a
biopsy safely, the patient may be enrolled without a biopsy.

- b) there is anatomic or mechanical compromise of critical organ function by
tumour (e.g., respiratory distress/failure, abdominal compartment syndrome,
urinary obstruction, etc.)

- c) Uncorrectable coagulopathy

- Age =30 years

- Written informed consent for trial entry

Exclusion Criteria:

- Any previous chemotherapy or currently receiving anti-cancer agents

- Recurrent disease

- Previously received a solid organ transplant; other than orthotopic liver
transplantation (OLT).

- Uncontrolled infection

- Unable to follow or comply with the protocol for any reason

- Second malignancy

- Pregnant or breastfeeding women