Ketamin in Kombination mit Neurofeedback-basiertem Lernen: Ein neuer pharmako-psychotherapeutischer Ansatz zur Behandlung der Kokainabhängigkeit

Drug: Ketamine;Drug: Placebo;Behavioral: real-time fMRI neurofeedback training;Behavioral: sham real-time fMRI neurofeedback training

Gender: All
Maximum age: 55 Years
Minimum age: 18 Years

Inclusion Criteria:

- Informed Consent as documented by signature

- Male and female cocaine users 18 to 55 years of age

- diagnostic and statisical manual (DSM)-5 diagnosis of CUD

- Willingness to comply with the study protocol as explained by investigator

- Normal level of language comprehension (German or Swiss-German)

Exclusion Criteria:

- Current or lifetime psychotic disorders

- History of severe substance-induced psychosis

- Current or lifetime bipolar I or II disorders

- Current suicidality

- Previous suicide attempts during the last 2 years

- Current severe alcohol use disorder

- Current severe cannabis use disorder

- Current moderate or severe stimulant use disorder (other than cocaine)

- Current moderate or severe benzodiazepine use disorder

- Current opioid use disorder

- First-degree relatives with psychotic disorders

- Beck Depression Inventory Score greater than 25

- Unmedicated or unstable hypertension

- Severe illness (e. g. myocardial ischemia or arrythmias, severe pulmonary secretions,
glaucoma, congestive heart failure or angina, significant renal or hepatic impairment)

- Acute infection (e. g. pulmonary or upper respiratory tract infection)

- Insufficient treated or uncorrected hyperthyroidism

- Severe central nervous system related traumas or disorders (e. g. stroke, cerebral
trauma with loss of consciousness over more than 24h, epilepsy)

- Increased intracranial pressure

- Medication directly affecting glutamate signaling (e. g. anticonvulsant medication)

- Any unstable psychoactive medication (no changes in compounds within last 4 weeks
before start of study)

- Pregnancy or lactation

- Women of childbearing potential with no use of medically accepted contraceptive (e. g.

condoms, contraceptive diaphragm, birth control pill, hormone injection, intrauterine
device)

- BMI>35

- Allergy, hypersensitivity, or other adverse reaction to previous use of ketamine

- Contradictions to magnetic resonance imaging

- Concurrent participation in other clinical study