Studie zur Untersuchung von Tau-Ablagerungen im Gehirn älterer Menschen mit Hilfe der Positronenemissionstomografie

Other: 18F-AV-1451 (Tau-PET tracer)

Gender: All
Maximum age: N/A
Minimum age: 50 Years

Inclusion Criteria:

1. Subject belongs to one of the following groups:

- No cognitive impairment

- Mild cognitive impairment according to Winblad et al., 2004

- Clinical diagnosis of dementia due to Alzheimer's disease compatible with DSM IV
criteria or revised NINCDS-ADRDA criteria

- Evidence of neurodegenerative disease other than AD

2. Written informed consent approved by the regulatory authorities

3. Age = 50 years, women must be without childbearing potential

4. Pre-existing PET information (11C-Pittsburgh Compound B, 18F-Flutemetamol) on cerebral
amyloid deposition

5. German speaking or sufficient knowledge of German language to perform study
assessments

6. Subject is willing and able to name an informant who can give adequate information on
the scales where informant input is required

Exclusion Criteria:

1. Evidence for cognitive impairment mainly attributed to a non-neurodegenerative
underlying medical condition (e.g. medication, brain tumor, severe heart
insufficiency, hepatic encephalopathy)

2. Evidence of larger cerebral infarcts, or lacunes in critical memory structures

3. Disease or other condition with a potential to interfere with study participation

4. Ongoing infection with human immunodeficiency virus (HIV) or any hepatitis virus

5. Active, acute or chronic leukemia

6. Severe illness likely to cause disability that interferes with study procedures in the
following years

7. Evidence of acute psychiatric disease (upon clinical decision) which may be a cause of
cognitive impairment. Patients with a history of major depression under stable
medication may be included. Patients with low dose intake of benzodiazepines may also
be included upon clinician's decision

8. Previous or current participation in anti-beta-amyloid or anti-tau therapeutic trials

9. MR exclusion criteria

10. PET exclusion criteria

11. Contraindications against venous puncture

12. Other condition that might pose a risk to the study subject in the opinion of the
investigator

13. Exclusion criteria for subproject CSF sampling