Die Effekte von DMT bei gesunden Probanden

Drug: Dimethyltryptamine (DMT);Drug: Saline

Inclusion Criteria:

- Age between 25 and 65 years old

- Sufficient understanding of the German language

- Understanding of procedures and risks associated with the study

- Willing to adhere to the protocol and signing of the consent form

- Willing to refrain from the consumption of illicit psychoactive substances during the
study

- Abstaining from xanthine-based liquids from the evenings prior to the study sessions
and during the sessions

- Willing not to operate heavy machinery within 6 h of DMT administration

- Willing to use double-barrier birth control throughout study participation

- Body mass index between 18-29 kg/m2

Exclusion Criteria:

- Chronic or acute medical condition

- Current or previous major psychiatric disorder

- Psychotic disorder or bipolar disorder in first-degree relatives

- Hypertension (SBP>140/90 mmHg) or hypotension (SBP<85 mmHg)

- Hallucinogenic substance use (not including cannabis) more than 20 times or any time
within the previous two months

- Pregnancy or current breastfeeding

- Participation in another clinical trial (currently or within the last 30 days)

- Use of medication that may interfere with the effects of the study medication

- Tobacco smoking (>10 cigarettes/day)

- Consumption of alcoholic beverages (>20 drinks/week)